Nizoral cream is a medication used to treat fungal infections of the skin. It contains the active ingredient ketoconazole, which is an antifungal agent. Nizoral cream is applied topically to the affected area(s) of the skin and works by killing or inhibiting the growth of fungi that cause infections.

Common fungal infections that Nizoral cream is used to treat include:

1. Athlete's foot (tinea pedis)
2. Jock itch (tinea cruris)
3. Ringworm (tinea corporis)
4. Fungal infections of the skin folds (such as intertrigo)

Nizoral cream contains the active ingredient ketoconazole, which belongs to a class of medications known as antifungals. Ketoconazole works by inhibiting the synthesis of ergosterol, an essential component for maintaining the integrity and function of fungal cell membranes.

Nizoral therefore disrupts the fungal cell membrane function ultimately causing fungal cell death. This action prevents the growth and proliferation of fungi, effectively treating fungal infections of the skin.

In addition to its direct antifungal activity, ketoconazole also exhibits some anti-inflammatory properties, which may contribute to its effectiveness in relieving symptoms associated with fungal infections, such as redness, itching, and inflammation.

When applied topically as a cream, Nizoral cream delivers ketoconazole directly to the affected area(s) of the skin, allowing for targeted treatment of fungal infections while minimizing systemic exposure and potential side effects.

The time can vary depending on several factors, including the severity of the fungal infection, the specific type of infection being treated, and individual differences in skin sensitivity and response to treatment. In general, noticeable improvement in symptoms may occur within a few days to a couple of weeks of starting treatment.

For mild fungal infections, such as athlete's foot or ringworm, some individuals may experience relief of symptoms within a few days of using Nizoral cream. However, it is important to continue using the cream as directed, even if symptoms improve, to ensure that the infection is fully treated and does not return.

For more severe or persistent fungal infections, it may take longer for Nizoral cream to work effectively. In such cases, it is important to follow the recommended treatment regimen and use the cream consistently until the infection clears up completely.

• BNF: Ketoconazole
• Patient Information Leaflet

Before using Nizoral Ketoconazole 2% Cream, please read the Patient Information Leaflet thoroughly and make sure to follow the instructions for use carefully.

• Wash the infected area and dry it well. As many skin conditions are contagious, you should keep a towel and flannel for your own use and not share it so that you do not infect anyone else.
• Apply the cream onto the infected area and surrounding skin.
• Wash your hands carefully after applying the cream to avoid spreading the infection to other parts of the body or to other people. Similarly, clothing which comes into contact with the infected areas, such as socks, should be washed and changed frequently.

For skin infections of the trunk, groin, feet and hands, apply Nizoral Ketoconazole 2% Cream to the affected and immediate surrounding area once or twice a day. Depending on the type of infection, treatment may last up to ten days.

For a full list of ingredients please read the Patient Information Leaflet.

Nizoral (Ketoconazole) 2% Cream contains the active substance: Ketoconazole.

Each gram of Nizoral Ketoconazole 2% Cream contains Ketoconazole 20 mg (2%)

Nizoral Ketoconazole 2% Cream also contains the inactive ingredients: purified water, propylene glycol, cetyl alcohol, stearyl alcohol, sorbitan stearate, polysorbate 60, polysorbate 80, sodium sulphite (E221) and isopropyl myristate

While it is generally well-tolerated, some people may experience side effects. Common side effects of Nizoral cream may include:

1. Skin irritation: This can manifest as redness, itching, burning, or stinging at the site of application.
2. Dry skin: Nizoral cream may cause dryness or flakiness of the skin.
3. Rash: Some individuals may develop a rash or allergic reaction to the cream.

It's important to note that not everyone will experience these side effects, and many people can use Nizoral cream without any problems. However, if you experience severe or persistent side effects, it's important to discontinue use and consult a healthcare professional. Additionally, be sure to read and follow the instructions provided with the medication, and inform your doctor of any other medications or supplements you are taking to avoid potential interactions.

When using Nizoral cream, there are several warnings and precautions that should be considered:

1. Allergic reactions: If you have a known allergy to ketoconazole or any other ingredients in Nizoral cream, you should not use it. Allergic reactions can range from mild skin irritation to severe reactions such as swelling, difficulty breathing, or anaphylaxis.
2. Avoid contact with eyes, nose, mouth, and other mucous membranes: Nizoral cream is for external use only. Avoid applying it to areas near the eyes, nose, mouth, or other mucous membranes to prevent irritation or adverse reactions.
3. Do not swallow: Nizoral cream is not meant to be ingested. If accidentally swallowed, seek medical attention immediately.
4. Skin irritation: Some individuals may experience skin irritation, redness, itching, or burning at the site of application. If these symptoms persist or worsen, discontinue use and consult a healthcare professional.

Always consult with a healthcare professional for personalized advice regarding the use of Nizoral cream, especially if you have any underlying medical conditions or concerns about its safety or effectiveness.

Nizoral cream can be used if you are pregnant or breast-feeding. Ask your doctor or pharmacist for advice before taking any medicine if you are pregnant or breast-feeding.